The German scientist Robert Koch used guinea pigs to discover that TB was caused by the bacterium Mycobacterium tuberculosis, in 1882. The sensitivity of the guinea pig to this and other infections, and the similarities of its immune defence system to that of humans, has made it important in the study of infectious diseases.
In 1919 research showed that inoculation of guinea pigs with a small amount of blood from Yellow Fever patients produced a mild reaction in the animals. The same animals were later resistant to infection with Leptospira icteroides, while animals which had received no previous inoculation, or which had been inoculated with blood from malaria patients, died. The guinea pigs were said to have ‘Aquired Immunity’ to L icteroides3.
In 1919 research showed that inoculation of guinea pigs with a small amount of blood from Yellow Fever patients produced a mild reaction in the animals. The same animals were later resistant to infection with Leptospira icteroides, while animals which had received no previous inoculation, or which had been inoculated with blood from malaria patients, died. The guinea pigs were said to have ‘Aquired Immunity’ to L icteroides3.
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