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The long gestation period of 59–72 days and mature central nervous system at birth means that guinea pigs are important in safety testing, particularly to prevent birth defects. However, it is the similarity of their immune system, and particularly their skin sensitivity, that led to their widespread use to test for allergic skin reactions.This use of guinea pigs to test for skin allergies has now been largely replaced by the milder local lymph node assay (LLNA), which uses mice and fewer of them. In 1999 many of these tests were carried out on guinea pigs, mostly for non-medical products. Now guinea pigs are rarely used.
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